campsis: Generic PK/PD Simulation Platform CAMPSIS

A generic, easy-to-use and intuitive pharmacokinetic/pharmacodynamic (PK/PD) simulation platform based on R packages 'rxode2' and 'mrgsolve'. CAMPSIS provides an abstraction layer over the underlying processes of writing a PK/PD model, assembling a custom dataset and running a simulation. CAMPSIS has a strong dependency to the R package 'campsismod', which allows to read/write a model from/to files and adapt it further on the fly in the R environment. Package 'campsis' allows the user to assemble a dataset in an intuitive manner. Once the user’s dataset is ready, the package is in charge of preparing the simulation, calling 'rxode2' or 'mrgsolve' (at the user's choice) and returning the results, for the given model, dataset and desired simulation settings.

Version: 1.5.5
Depends: campsismod (≥ 1.1.0), R (≥ 4.0.0)
Imports: assertthat, digest, dplyr, furrr, future, ggplot2, MASS, methods, plyr, progressr, purrr, rlang, stats, tibble, tidyr
Suggests: bookdown, devtools, gridExtra, knitr, mrgsolve, pkgdown, rmarkdown, roxygen2, rxode2, stringr, testthat, tictoc, vdiffr, xfun
Published: 2024-11-26
DOI: 10.32614/CRAN.package.campsis
Author: Nicolas Luyckx [aut, cre]
Maintainer: Nicolas Luyckx <nicolas.luyckx at calvagone.com>
BugReports: https://github.com/Calvagone/campsis/issues
License: GPL (≥ 3)
URL: https://github.com/Calvagone/campsis, https://calvagone.github.io/, https://calvagone.github.io/campsis.doc/
NeedsCompilation: no
Language: en-US
Materials: README NEWS
CRAN checks: campsis results

Documentation:

Reference manual: campsis.pdf
Vignettes: Get started with CAMPSIS (source, R code)
Create your dataset (source, R code)
Variability levels (source, R code)
Covariates (source, R code)
Bioavailability (source, R code)
Lag time (source, R code)
Infusions (source, R code)
Inter-occasion variability (source, R code)
Initial conditions (source, R code)
Simple dose adaptations (source, R code)
Replicate your study (source, R code)
Scenarios (source, R code)
Time-varying covariates (source, R code)
Interruption events (source, R code)
Complex PK/PD models from literature (source, R code)
PK/PD model library (source, R code)
Progress bar (source, R code)
Run your simulation in parallel (source, R code)

Downloads:

Package source: campsis_1.5.5.tar.gz
Windows binaries: r-devel: campsis_1.5.5.zip, r-release: campsis_1.5.4.zip, r-oldrel: campsis_1.5.5.zip
macOS binaries: r-release (arm64): campsis_1.5.5.tgz, r-oldrel (arm64): campsis_1.5.5.tgz, r-release (x86_64): campsis_1.5.5.tgz, r-oldrel (x86_64): campsis_1.5.5.tgz
Old sources: campsis archive

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